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ACAT1 Antibody (aa221-270)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P24752 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45kDa |
| Dilution | ELISA (1:40000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 38 |
|---|---|
| Other Names | Acetyl-CoA acetyltransferase, mitochondrial, 2.3.1.9, Acetoacetyl-CoA thiolase, T2, ACAT1, ACAT, MAT |
| Target/Specificity | ACAT1 Antibody detects endogenous levels of total ACAT1 protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | ACAT1 Antibody (aa221-270) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ACAT1 |
|---|---|
| Synonyms | ACAT, MAT |
| Function | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:17371050, PubMed:1715688, PubMed:7728148, PubMed:9744475). |
| Cellular Location | Mitochondrion. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a major role in ketone body metabolism.
References
Fukao T.,et al.J. Clin. Invest. 86:2086-2092(1990).
Kano M.,et al.Gene 109:285-290(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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