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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CLDN1 / Claudin 1 Antibody (aa162-211)   

CLDN1 / Claudin 1 Antibody (aa162-211)

Rabbit Polyclonal Antibody

     
  • WB - CLDN1 / Claudin 1 Antibody (aa162-211) ALS14477
    Western blot of extracts from HeLa cells, using Claudin 1 Antibody.
  • IHC - CLDN1 / Claudin 1 Antibody (aa162-211) ALS14477
    Anti-CLDN1 / Claudin 1 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O95832
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 23kDa
Dilution ELISA (1:5000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 9076
Other Names Claudin-1, Senescence-associated epithelial membrane protein, CLDN1, CLD1, SEMP1
Target/Specificity Claudin 1 Antibody detects endogenous levels of total Claudin 1 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCLDN1 / Claudin 1 Antibody (aa162-211) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLDN1
Synonyms CLD1, SEMP1
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
Cellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Tissue Location Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis
Volume 50 µl
Research Areas
Citations (0)

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Background

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.

References

Swisshelm K.L.,et al.Gene 226:285-295(1999).
Mitic L.M.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Halford S.,et al.Cytogenet. Cell Genet. 88:217-217(2000).
Kraemer F.,et al.Hum. Genet. 107:249-256(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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$ 395.00
Cat# ALS14477
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