|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:20000), IF (1:100-1:500), IHC-P (1:100), WB (1:500-1:1000) ,|
|Other Names||Neurofibromin, Neurofibromatosis-related protein NF-1, Neurofibromin truncated, NF1|
|Target/Specificity||NF1 Antibody detects endogenous levels of total NF1 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||Neurofibromin / NF1 Antibody (aa1551-1600) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.|
|Cellular Location||Nucleus. Nucleus, nucleolus|
|Tissue Location||Detected in brain, peripheral nerve, lung, colon and muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
Bernards A.,et al.DNA Cell Biol. 11:727-734(1992).
Wallace M.R.,et al.Science 249:181-186(1990).
Wallace M.R.,et al.Science 250:1749-1749(1990).
Marchuk D.A.,et al.Genomics 11:931-940(1991).
Suzuki H.,et al.Biochem. Biophys. Res. Commun. 187:984-990(1992).
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