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LGALS8 / Galectin 8 Antibody (aa61-110)

Rabbit Polyclonal Antibody

     
  • WB - LGALS8 / Galectin 8 Antibody (aa61-110) ALS14486
    Western blot of extracts from NIH-3T3 cells, using LEG8 Antibody.
    detail
  • IHC - LGALS8 / Galectin 8 Antibody (aa61-110) ALS14486
    Anti-LGALS8 / Galectin-8 antibody IHC of human tonsil.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O00214
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 36kDa
Dilution ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 3964
Other Names Galectin-8, Gal-8, Po66 carbohydrate-binding protein, Po66-CBP, Prostate carcinoma tumor antigen 1, PCTA-1, LGALS8
Target/Specificity LEG8 Antibody detects endogenous levels of total LEG8 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsLGALS8 / Galectin 8 Antibody (aa61-110) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LGALS8 (HGNC:6569)
Function Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).
Cellular Location Cytoplasmic vesicle. Cytoplasm, cytosol
Tissue Location Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy
Research Areas
Citations (0)
citation

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Background

Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.

References

Su Z.-Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:7252-7257(1996).
Hadari Y.R.,et al.Trends Glycosci. Glycotechnol. 9:103-112(1997).
Brichory F.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Maier C.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Gopalkrishnan R.V.,et al.Oncogene 19:4405-4416(2000).

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Discontinued
Cat# ALS14486
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