|Application ||WB, IHC-P, E|
|Reactivity||Human, Rat, Rabbit, Monkey, Pig, Bovine, Dog|
|Dilution||ELISA (1:64000), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q, GNAQ, GAQ|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||GNAQ Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).|
|Cellular Location||Nucleus. Membrane. Nucleus membrane. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.|
|Tissue Location||Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).
Dong Q.,et al.Genomics 30:470-475(1995).
Chen B.,et al.Biochim. Biophys. Acta 1281:125-128(1996).
Johnson G.J.,et al.Biochem. J. 318:1023-1031(1996).
Gabbeta J.,et al.Thromb. Res. 91:29-32(1998).
Bai X.H.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
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