|Application ||WB, IHC-P, IF, E|
|Dilution||IF (40 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Rap guanine nucleotide exchange factor 6, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ-GEF2, RA-GEF-2, RAPGEF6, PDZGEF2|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||RAPGEF6 Antibody (clone 2C5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Upon binding to M-Ras, it translocates to the plasma membrane|
|Tissue Location||Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
Kuiperij H.B.,et al.Biochim. Biophys. Acta 1593:141-149(2003).
Banville D.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Gao X.,et al.J. Biol. Chem. 276:42219-42225(2001).
Schmutz J.,et al.Nature 431:268-274(2004).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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