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MDH1 Antibody (clone 1D2)

Mouse Monoclonal Antibody

     
  • WB - MDH1 Antibody (clone 1D2) ALS14507
    Western blot of MDH1 expression in transfected 293T cell line by MDH1 monoclonal antibody, clone...
    detail
  • IHC - MDH1 Antibody (clone 1D2) ALS14507
    Anti-MDH1 antibody IHC of human adrenal.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P40925
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1D2
Calculated MW 36kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 4190
Other Names Malate dehydrogenase, cytoplasmic, 1.1.1.37, Cytosolic malate dehydrogenase, Diiodophenylpyruvate reductase, 1.1.1.96, MDH1, MDHA
Target/Specificity Human MDH1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsMDH1 Antibody (clone 1D2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MDH1 {ECO:0000303|PubMed:34012073, ECO:0000312|HGNC:HGNC:6970}
Function Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2- hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073).
Cellular Location Cytoplasm, cytosol.
Research Areas
Citations (0)
citation

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References

Tanaka T.,et al.Genomics 32:128-130(1996).
Lo A.S.Y.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 533.50
Cat# ALS14507
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