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MFGE8 / MFG-E8 Antibody (clone 1E7)

Mouse Monoclonal Antibody

     
  • IP - MFGE8 / MFG-E8 Antibody (clone 1E7) ALS14511
    Immunoprecipitation of MFGE8 transfected lysate using anti-MFGE8 monoclonal antibody and Protein...
  • IHC - MFGE8 / MFG-E8 Antibody (clone 1E7) ALS14511
    Anti-MFGE8 / MFG-E8 antibody IHC of human lung, epithelium.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession Q08431
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1E7
Calculated MW 43kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 4240
Other Names Lactadherin, Breast epithelial antigen BA46, HMFG, MFGM, Milk fat globule-EGF factor 8, MFG-E8, SED1, Lactadherin short form, Medin, MFGE8
Target/Specificity Human MFGE8 / MFG-E8
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsMFGE8 / MFG-E8 Antibody (clone 1E7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MFGE8
Function Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.
Cellular Location Membrane; Peripheral membrane protein Secreted
Tissue Location Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas
Research Areas
Citations (0)

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Background

Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.

References

Couto J.R.,et al.DNA Cell Biol. 15:281-286(1996).
Sivashanmugam P.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS14511
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