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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CCN3 / NOV Antibody (clone 2G8)   

CCN3 / NOV Antibody (clone 2G8)

Mouse Monoclonal Antibody

     
  • WB - CCN3 / NOV Antibody (clone 2G8) ALS14529
    Western blot of NOV expression in transfected 293T cell line by NOV monoclonal antibody, clone 2G8.
  • IP - CCN3 / NOV Antibody (clone 2G8) ALS14529
    Immunoprecipitation of NOV transfected lysate using anti-NOV monoclonal antibody and Protein A...
  • IHC - CCN3 / NOV Antibody (clone 2G8) ALS14529
    Anti-NOV / CCN3 antibody IHC of human pancreas.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, IP
Primary Accession P48745
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2G8
Calculated MW 39kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 4856
Other Names Protein NOV homolog, NovH, CCN family member 3, Insulin-like growth factor-binding protein 9, IBP-9, IGF-binding protein 9, IGFBP-9, Nephroblastoma-overexpressed gene protein homolog, NOV, CCN3, IGFBP9, NOVH
Target/Specificity Human NOV / CCN3
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCCN3 / NOV Antibody (clone 2G8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOV
Synonyms CCN3, IGFBP9, NOVH
Function Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti- inflammatory effects occur secondary to the inhibition of NF- kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).
Cellular Location Secreted. Cytoplasm. Cell junction, gap junction. Note=Localizes at the Gap junction in presence of GJA1/CX43. {ECO:0000250|UniProtKB:Q9QZQ5}
Tissue Location Expressed in endiothelial cells (at protein level) (PubMed:21063504). Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.
Research Areas
Citations (0)

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Background

Immediate-early protein likely to play a role in cell growth regulation.

References

Martinerie C.,et al.Oncogene 9:2729-2732(1994).
Martinerie C.,et al.Oncogene 12:1479-1492(1996).
Jiang D.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 450.00
Cat# ALS14529
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