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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   FOS / c-FOS Antibody (clone 1H8)   

FOS / c-FOS Antibody (clone 1H8)

Mouse Monoclonal Antibody

     
  • IHC - FOS / c-FOS Antibody (clone 1H8) ALS14539
    Anti-FOS / c-FOS antibody IHC of human brain, cortex.
  • IHC - FOS / c-FOS Antibody (clone 1H8) ALS14539
    Anti-FOS / c-FOS antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P01100
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1H8
Calculated MW 41kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 2353
Other Names Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, FOS, G0S7
Target/Specificity Human FOS / c-FOS
Reconstitution & Storage For long term, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsFOS / c-FOS Antibody (clone 1H8) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOS
Synonyms G0S7
Function Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Cellular Location Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30
Volume 50 µl
Research Areas
Citations (0)

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Background

Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

References

van Straaten F.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Roux P.,et al.Oncogene 6:2155-2160(1991).

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$ 450.00
Cat# ALS14539
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