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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Syndapin I / PACSIN1 Antibody   

Syndapin I / PACSIN1 Antibody

Goat Polyclonal Antibody

     
  • WB - Syndapin I / PACSIN1 Antibody ALS14548
    PACSIN1 antibody (1 ug/ml) staining of Human Brain (hippocampus) lysate (35 ug protein/ml in...
  • IHC - Syndapin I / PACSIN1 Antibody ALS14548
    Anti-PACSIN1 antibody IHC of human brain, cerebellum.
  • IHC - Syndapin I / PACSIN1 Antibody ALS14548
    Anti-PACSIN1 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BY11
Reactivity Human, Pig
Host Goat
Clonality Polyclonal
Calculated MW 51kDa
Dilution ELISA (1:32000), IHC-P (2.5-3.75 µg/ml), WB (0.03-0.1 µg/ml)
Additional Information
Gene ID 29993
Other Names Protein kinase C and casein kinase substrate in neurons protein 1, Syndapin-1, PACSIN1, KIAA1379
Target/Specificity Human PACSIN1. Reported variants represent identical protein (NP_065855.1; NP_001186512.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSyndapin I / PACSIN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PACSIN1
Synonyms KIAA1379
Function Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
Cellular Location Cytoplasm. Cell projection. Cell junction, synapse, synaptosome Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse. Cytoplasm, cytosol Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain.
Tissue Location Highly expressed in brain and, at much lower levels, in heart and pancreas.
Research Areas
Citations (0)

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Background

Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.

References

Sumoy L.,et al.Gene 262:199-205(2001).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Goh S.L.,et al.PLoS ONE 7:E51628-E51628(2012).

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$ 395.00
Cat# ALS14548
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