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Syndapin I / PACSIN1 Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BY11 |
| Reactivity | Human, Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 51kDa |
| Dilution | ELISA (1:32000), IHC-P (2.5-3.75 µg/ml), WB (0.03-0.1 µg/ml) |
| Gene ID | 29993 |
|---|---|
| Other Names | Protein kinase C and casein kinase substrate in neurons protein 1, Syndapin-1, PACSIN1, KIAA1379 |
| Target/Specificity | Human PACSIN1. Reported variants represent identical protein (NP_065855.1; NP_001186512.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | Syndapin I / PACSIN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PACSIN1 |
|---|---|
| Synonyms | KIAA1379 |
| Function | Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. |
| Cellular Location | Cytoplasm. Cell projection. Synapse, synaptosome. Cell projection, ruffle membrane. Membrane; Peripheral membrane protein Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse. Cytoplasm, cytosol Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. |
| Tissue Location | Highly expressed in brain and, at much lower levels, in heart and pancreas. |
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Background
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
References
Sumoy L.,et al.Gene 262:199-205(2001).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Goh S.L.,et al.PLoS ONE 7:E51628-E51628(2012).
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