|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Hamster, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||ELISA (1:32000), IHC-P (2.5-3.75 µg/ml), WB (1-1.5 µg/ml)|
|Other Names||Guanine nucleotide exchange factor VAV2, VAV-2, VAV2|
|Target/Specificity||Human VAV2. This antobody is expected to recognise both reported isoforms (NP_001127870.1 and NP_003362.2).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||VAV2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Henske E.P.,et al.Ann. Hum. Genet. 59:25-37(1995).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mancini U.M.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
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