|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:8000), IHC-P (2.5-3.75 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Melanocortin receptor 5, MC5-R, MC-2, MC5R|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||MC5R / MC5 Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in the brain but not in the melanoma cells|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
Chhajlani V.,et al.Biochem. Biophys. Res. Commun. 195:866-873(1993).
Griffon N.,et al.Biochem. Biophys. Res. Commun. 200:1007-1014(1994).
Fathi Z.,et al.Neurochem. Res. 20:107-113(1995).
Kopatz S.A.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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