|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog|
|Calculated MW||27077 Da|
|Dilution||ELISA (1:32000), IHC-P (2.5-3.75 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Clathrin light chain A, Lca, CLTA|
|Target/Specificity||Human CLTA. This antibody is expected to recognize all reported isoforms of light chains a and b.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CLTA / CLTB Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge (PubMed:15858577, PubMed:21297582).|
|Cellular Location||Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.|
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