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Rabbit Polyclonal Antibody
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P61956 |
| Other Accession | P55854 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 10871 Da |
| Dilution | IHC-P (10 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 6613 |
|---|---|
| Other Names | Small ubiquitin-related modifier 2, SUMO-2, HSMT3, SMT3 homolog 2 {ECO:0000312|HGNC:HGNC:11125}, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3B, Smt3B, SUMO2 (HGNC:11125) |
| Target/Specificity | Synthetic peptide corresponding to human SUMO2/3. Cross reacts with mouse SUMO2/3.The peptides used to generate this antibody correspond to amino acids 4-16 of human Sumo2/3 and amino acids 61 to 76 of Sumo2 (aa 60-75 of Sumo 3). |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
| Precautions | SUMO2 + SUMO3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SUMO2 (HGNC:11125) |
|---|---|
| Function | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). |
| Cellular Location | Nucleus. Nucleus, PML body. |
| Tissue Location | Broadly expressed. |
Citations (0)
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info@abgent.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 395.00
Cat# ALS14577
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