UBE2F Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q969M7 |
Reactivity | Human, Mouse, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 21kDa |
Dilution | IHC-P (2.5-3.75 µg/ml), WB (0.05-0.2 µg/ml), |
Gene ID | 140739 |
---|---|
Other Names | NEDD8-conjugating enzyme UBE2F, 6.3.2.-, NEDD8 carrier protein UBE2F, NEDD8 protein ligase UBE2F, NEDD8-conjugating enzyme 2, Ubiquitin-conjugating enzyme E2 F, UBE2F, NCE2 |
Target/Specificity | Human UBE2F / UBE2F. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | UBE2F Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UBE2F |
---|---|
Synonyms | NCE2 |
Function | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. |
Tissue Location | Widely expressed (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
References
Gladysheva T.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Huang D.T.,et al.Mol. Cell 33:483-495(2009).
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