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SETD7 / SET7 Antibody (aa131-145)

Rabbit Polyclonal Antibody

     
  • WB - SETD7 / SET7 Antibody (aa131-145) ALS14583
    Western blot analysis for Set7/9 using antibody at 1:500 on 20 ug of HeLa whole cell lysate.
    detail
  • IHC - SETD7 / SET7 Antibody (aa131-145) ALS14583
    Anti-SETD7 / SET7 antibody IHC of human small intestine.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8WTS6
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Dilution IHC-P (1:100), WB (1:500-1:1000),
Additional Information
Gene ID 80854
Other Names Histone-lysine N-methyltransferase SETD7, 2.1.1.43, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, SETD7, KIAA1717, KMT7, SET7, SET9
Target/Specificity Two synthetic peptides corresponding to amino acids 131-145 (GEVNEDGEMTGEKIA) and336-352 (GYDHSPPGKSGPEAPEW) of human Set7/9 were used as immunogen; GenBank Accession No. NP_085151.1. Thesesequences are 100% conserved between human, mouse and rat.
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsSETD7 / SET7 Antibody (aa131-145) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SETD7
Function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12588998, PubMed:12540855, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12588998, PubMed:12540855, PubMed:16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:16141209, PubMed:12588998). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). Has also methyltransferase activity toward non- histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:35210392, PubMed:15525938, PubMed:16415881). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:17108971, PubMed:15525938, PubMed:16415881). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity).
Cellular Location Nucleus. Chromosome
Tissue Location Widely expressed. Expressed in pancreatic islets.
Citations (0)
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Background

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

References

Wang H.,et al.Mol. Cell 8:1207-1217(2001).
Nishioka K.,et al.Genes Dev. 16:479-489(2002).
Hillier L.W.,et al.Nature 434:724-731(2005).
Nagase T.,et al.DNA Res. 7:347-355(2000).
Martens J.H.,et al.Mol. Cell. Biol. 23:1808-1816(2003).

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$ 467.50
Cat# ALS14583
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