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DLX5 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - DLX5 Antibody (Internal) ALS14585
    DLX5 antibody (1 ug/ml) staining of Human Bone Marrow lysate (35 ug protein/ml in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P56178
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 32kDa
Dilution ELISA (1:32000), IHC-P (2.5-3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 1749
Other Names Homeobox protein DLX-5, DLX5
Target/Specificity Human DLX5.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDLX5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLX5
Function Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Volume 50 µl
Research Areas
Citations (0)

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Background

Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Simeone A.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:2250-2254(1994).
Willis D.M.,et al.J. Biol. Chem. 277:37280-37291(2002).
Xu J.,et al.J. Biol. Chem. 284:20593-20601(2009).

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$ 395.00
Cat# ALS14585
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