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FBXO4 / FBX4 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - FBXO4 / FBX4 Antibody (Internal) ALS14590
    Anti-FBXO4 antibody IHC of human tonsil.
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  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9UKT5
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 44kDa
Dilution ELISA (1:8000), IHC-P (2.5-3.75 µg/ml),
Additional Information
Gene ID 26272
Other Names F-box only protein 4, FBXO4, FBX4
Target/Specificity Human FBXO4. This antibody is expected to recognize isoform 1 and 2 (NP_036308.1; NP_277019.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsFBXO4 / FBX4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO4
Synonyms FBX4
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18598945, PubMed:10531035, PubMed:29142209, PubMed:20181953). Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation (PubMed:18598945). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q8CHQ0}.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

References

Cenciarelli C.,et al.Curr. Biol. 9:1177-1179(1999).
Winston J.T.,et al.Curr. Biol. 9:1180-1182(1999).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Lee T.H.,et al.J. Biol. Chem. 281:759-768(2006).
Barbash O.,et al.Cancer Cell 14:68-78(2008).

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Discontinued
Cat# ALS14590
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