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FIS1 Antibody (aa11-25)

Rabbit Polyclonal Antibody

     
  • WB - FIS1 Antibody (aa11-25) ALS14595
    Western blot of Fis1 in A) HeLa and B) NIH 3T3 cell lysate using antibody at 1:1000 dilution.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9Y3D6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 17kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 51024
Other Names Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11
Target/Specificity A peptide corresponding to amino acids 11-25 of human Fis1 protein was used as the immunogen.
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsFIS1 Antibody (aa11-25) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FIS1
Synonyms TTC11
Function Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein
Research Areas
Citations (0)

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Background

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

References

Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Hillier L.W.,et al.Nature 424:157-164(2003).
Bienvenut W.V.,et al.Submitted (JUN-2005) to UniProtKB.
James D.I.,et al.J. Biol. Chem. 278:36373-36379(2003).
Yoon Y.,et al.Mol. Cell. Biol. 23:5409-5420(2003).

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$ 395.00
Cat# ALS14595
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