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FIS1 Antibody (aa11-25)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9Y3D6 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 51024 |
|---|---|
| Other Names | Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11 |
| Target/Specificity | A peptide corresponding to amino acids 11-25 of human Fis1 protein was used as the immunogen. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
| Precautions | FIS1 Antibody (aa11-25) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FIS1 |
|---|---|
| Synonyms | TTC11 |
| Function | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:12783892, PubMed:12861026, PubMed:14996942, PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:12861026, PubMed:16118244, PubMed:23283981, PubMed:23530241, PubMed:24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed:23530241, PubMed:24196833). Also mediates peroxisomal fission (PubMed:16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed:12783892). |
| Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
References
Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Hillier L.W.,et al.Nature 424:157-164(2003).
Bienvenut W.V.,et al.Submitted (JUN-2005) to UniProtKB.
James D.I.,et al.J. Biol. Chem. 278:36373-36379(2003).
Yoon Y.,et al.Mol. Cell. Biol. 23:5409-5420(2003).
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