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HSD11B1 / HSD11B Antibody

Rabbit Polyclonal Antibody

     
  • IHC - HSD11B1 / HSD11B Antibody ALS14614
    Anti-HSD11B1 antibody IHC of human lung, macrophages.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P28845
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 32kDa
Dilution IHC-P (1:100), WB (1:500-1:3000),
Additional Information
Gene ID 3290
Other Names Corticosteroid 11-beta-dehydrogenase isozyme 1, 1.1.1.146, 11-beta-hydroxysteroid dehydrogenase 1, 11-DH, 11-beta-HSD1, HSD11B1, HSD11, HSD11L
Target/Specificity This Polyclonal antibody is directed against human 11-Hydroxysteroid Dehydrogenase(Type 1)protein. The product was purified from serum by protein A chromatography. Expect reactivity with human 11-Hydroxysteroid Dehydrogenase(Type 1). Cross-reactivity ...
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHSD11B1 / HSD11B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSD11B1
Synonyms HSD11, HSD11L, SDR26C1
Function Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Cellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein
Tissue Location Widely expressed. Highest expression in liver.
Volume 50 µl
Research Areas
Citations (0)

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Background

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

References

Tannin G.M.,et al.J. Biol. Chem. 266:16653-16658(1991).
Draper N.,et al.J. Clin. Endocrinol. Metab. 87:4984-4990(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14614
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