|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Protein patched homolog 1, PTC, PTC1, PTCH1, PTCH|
|Target/Specificity||Patched Antibody detects endogenous levels of total Patched protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||PTCH1 / Patched Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Johnson R.L.,et al.Science 272:1668-1671(1996).
Hahn H.,et al.J. Biol. Chem. 271:12125-12128(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Nagao K.,et al.Genomics 85:462-471(2005).
Shimokawa T.,et al.Oncogene 26:4889-4896(2007).
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