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PTCH1 / Patched Antibody (aa1-50)

Rabbit Polyclonal Antibody

     
  • WB - PTCH1 / Patched Antibody (aa1-50) ALS14617
    Western blot of extracts from mouse muscle cells, using Patched Antibody.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q13635
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 161kDa
Dilution ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 5727
Other Names Protein patched homolog 1, PTC, PTC1, PTCH1, PTCH
Target/Specificity Patched Antibody detects endogenous levels of total Patched protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsPTCH1 / Patched Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTCH1
Synonyms PTCH
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin
Volume 50 µl
Research Areas
Citations (0)

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Background

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

References

Johnson R.L.,et al.Science 272:1668-1671(1996).
Hahn H.,et al.J. Biol. Chem. 271:12125-12128(1996).
Humphray S.J.,et al.Nature 429:369-374(2004).
Nagao K.,et al.Genomics 85:462-471(2005).
Shimokawa T.,et al.Oncogene 26:4889-4896(2007).

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$ 395.00
Cat# ALS14617
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