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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CDH23 / Cadherin 23 Antibody (aa61-110)   

CDH23 / Cadherin 23 Antibody (aa61-110)

Rabbit Polyclonal Antibody

     
  • IF - CDH23 / Cadherin 23 Antibody (aa61-110) ALS14633
    Immunofluorescence of HeLa cells, using CDH23 Antibody.
  • IHC - CDH23 / Cadherin 23 Antibody (aa61-110) ALS14633
    Anti-CDH23 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession Q9H251
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 369kDa
Dilution ELISA (1:10000), IF (1:100-1:500), IHC-P (1:100)
Additional Information
Gene ID 64072
Other Names Cadherin-23, Otocadherin, CDH23, KIAA1774, KIAA1812
Target/Specificity CDH23 Antibody detects endogenous levels of total CDH23 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCDH23 / Cadherin 23 Antibody (aa61-110) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDH23
Synonyms KIAA1774, KIAA1812
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Particularly strong expression in the retina. Found also in the cochlea
Volume 50 µl
Research Areas
Citations (0)

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Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.

References

Bolz H.,et al.Nat. Genet. 27:108-112(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Lagziel A.,et al.Dev. Biol. 280:295-306(2005).
Deloukas P.,et al.Nature 429:375-381(2004).
Nagase T.,et al.DNA Res. 8:85-95(2001).

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$ 395.00
Cat# ALS14633
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