HP / Haptoglobin Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | P00738 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Dilution | IHC-P (2.5 µg/ml) |
Gene ID | 3240 |
---|---|
Other Names | Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP |
Target/Specificity | Recognizes human haptoglobin. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | HP / Haptoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HP |
---|---|
Function | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. |
Cellular Location | Secreted. |
Tissue Location | Expressed by the liver and secreted in plasma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
References
van der Straten A.,et al.EMBO J. 2:1003-1007(1983).
Yang F.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:5875-5879(1983).
van der Straten A.,et al.FEBS Lett. 168:103-107(1984).
Brune J.L.,et al.Nucleic Acids Res. 12:4531-4538(1984).
Bensi G.,et al.EMBO J. 4:119-126(1985).
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