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NDRG4 Antibody (clone 2G3)

Mouse Monoclonal Antibody

     
  • WB - NDRG4 Antibody (clone 2G3) ALS14653
    Antibody ALS14653 Western blot of NDRG4 expression in Raw 264.7.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9ULP0
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 2G3
Calculated MW 38kDa
Dilution IHC-P (1:100), WB (1:500-1:1000),
Additional Information
Gene ID 65009
Other Names Protein NDRG4, Brain development-related molecule 1, N-myc downstream-regulated gene 4 protein, Vascular smooth muscle cell-associated protein 8, SMAP-8, NDRG4, BDM1, KIAA1180
Target/Specificity Human NDRG4
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsNDRG4 Antibody (clone 2G3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NDRG4
Synonyms BDM1, KIAA1180
Function Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
Cellular Location Cytoplasm, cytosol
Tissue Location Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
Research Areas
Citations (0)

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Background

Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

References

Zhou R.-H.,et al.Genomics 73:86-97(2001).
Qu X.,et al.Mol. Cell. Biochem. 229:35-44(2002).
Nishimoto S.,et al.Eur. J. Biochem. 270:2521-2531(2003).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 450.00
Cat# ALS14653
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