NDRG4 Antibody (clone 2G3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9ULP0 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2G3 |
Calculated MW | 38kDa |
Dilution | IHC-P (1:100), WB (1:500-1:1000), |
Gene ID | 65009 |
---|---|
Other Names | Protein NDRG4, Brain development-related molecule 1, N-myc downstream-regulated gene 4 protein, Vascular smooth muscle cell-associated protein 8, SMAP-8, NDRG4, BDM1, KIAA1180 |
Target/Specificity | Human NDRG4 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | NDRG4 Antibody (clone 2G3) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NDRG4 |
---|---|
Synonyms | BDM1, KIAA1180 |
Function | Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. |
Cellular Location | Cytoplasm, cytosol |
Tissue Location | Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells |
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Background
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
References
Zhou R.-H.,et al.Genomics 73:86-97(2001).
Qu X.,et al.Mol. Cell. Biochem. 229:35-44(2002).
Nishimoto S.,et al.Eur. J. Biochem. 270:2521-2531(2003).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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