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TRPC4 Antibody (aa930-947, clone S77-15)

Mouse Monoclonal Antibody

     
  • IF - TRPC4 Antibody (aa930-947, clone S77-15) ALS14654
    TrpC4 (S77-15), Human hippocampus.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, IP
Primary Accession Q9UBN4
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S77-15
Calculated MW 112kDa
Dilution ICC (0.1-1 µg/ml), IHC-P (1:50), IP (1-10 µg/ml), WB (1-10 µg/ml) ,
Additional Information
Gene ID 7223
Other Names Short transient receptor potential channel 4, TrpC4, Trp-related protein 4, hTrp-4, hTrp4, TRPC4
Target/Specificity Detects ~110 kD protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsTRPC4 Antibody (aa930-947, clone S77-15) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPC4
Function Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor
Tissue Location Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain
Volume 50 µl
Research Areas
Citations (0)

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Background

Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.

References

McKay R.R.,et al.Biochem. J. 351:735-746(2000).
Mery L.,et al.FEBS Lett. 487:377-383(2001).
Schaefer M.,et al.J. Biol. Chem. 277:3752-3759(2002).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14654
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