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E2F1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - E2F1 Antibody (Internal) ALS14659
    Anti-E2F1 antibody IHC of human thymus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q01094
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Dilution WB (1:1000-1:5000)
Additional Information
Gene ID 1869
Other Names Transcription factor E2F1, E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1, E2F1, RBBP3
Target/Specificity Human 47 kD E2F-1 acK120 and acK125
Reconstitution & Storage Store lyophilized at -20°C for 2 years. Stable at 4°C for at least one month or for six months in aliquots at -20°C. Avoid freeze/thaw cycles.
PrecautionsE2F1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name E2F1
Synonyms RBBP3
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Cellular Location Nucleus.
Volume 100 µl
Research Areas
Citations (0)

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Background

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis.

References

Helin K.,et al.Cell 70:337-350(1992).
Kaelin W.G. Jr.,et al.Cell 70:351-364(1992).
Shan B.,et al.Mol. Cell. Biol. 12:5620-5631(1992).
Neuman E.,et al.Gene 173:163-169(1996).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 395.00
Cat# ALS14659
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