|Application ||IHC-P, IF, E|
|Dilution||ELISA (1:20000), IF (1:100-1:500), IHC-P (10 µg/ml)|
|Other Names||Mucin-16, MUC-16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125, MUC16, CA125|
|Target/Specificity||MUC16 Antibody detects endogenous levels of total MUC16 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||MUC16 / CA125 Antibody (aa13311-13360) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain|
|Tissue Location||Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas|
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Provided below are standard protocols that you may find useful for product applications.
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
O'Brien T.J.,et al.Tumor Biol. 23:154-169(2002).
O'Brien T.J.,et al.Tumor Biol. 22:348-366(2001).
Yin B.W.T.,et al.J. Biol. Chem. 276:27371-27375(2001).
Lloyd K.O.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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