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CXCR3 Antibody (aa161-210)

Rabbit Polyclonal Antibody

     
  • WB - CXCR3 Antibody (aa161-210) ALS14672
    Western blot of extracts from K562 cells, using CXCR3 Antibody.
  • IHC - CXCR3 Antibody (aa161-210) ALS14672
    Anti-CXCR3 antibody IHC of human brain, cortex neurons.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P49682
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Dilution ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 2833
Other Names C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor, CD183, CXCR3, GPR9
Target/Specificity CXCR3 Antibody detects endogenous levels of total CXCR3 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCXCR3 Antibody (aa161-210) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CXCR3
Synonyms GPR9
Function Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 3: Mediates the activity of CXCL11.
Cellular Location Isoform 1: Cell membrane; Multi-pass membrane protein
Tissue Location Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level)
Volume 50 µl
Research Areas
Citations (0)

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Background

Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 3: Mediates the activity of CXCL11.

References

Loetscher M.,et al.J. Exp. Med. 184:963-969(1996).
Lasagni L.,et al.J. Exp. Med. 197:1537-1549(2003).
Petrai I.,et al.Int. J. Biochem. Cell Biol. 40:1764-1774(2008).
Gutierrez J.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS14672
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