ABCA5 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q8WWZ7 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 187kDa |
Dilution | IHC-P (1:100) |
Gene ID | 23461 |
---|---|
Other Names | ATP-binding cassette sub-family A member 5, ABCA5, KIAA1888 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | ABCA5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABCA5 (HGNC:35) |
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Synonyms | KIAA1888 |
Function | Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity). |
Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8CF82}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CF82}. Lysosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Late endosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Cell membrane {ECO:0000250|UniProtKB:Q8K448}. Note=Localized at cell membrane under high cholesterol levels. {ECO:0000250|UniProtKB:Q8K448} |
Tissue Location | Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath (PubMed:24831815). Expressed in multiple regions of the brain, including the hippocampus, superior frontal and inferior temporal cortices (PubMed:25125465). Strongly expressed in neurons and moderately in microglia, with only weak expression in astrocytes and oligodendrocytes (PubMed:25125465). {ECO:0000269|PubMed:12504089, ECO:0000269|PubMed:24831815, ECO:0000269|PubMed:25125465, ECO:0000269|Ref.1} |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in the processing of autolysosomes.
References
Arnould I.,et al.GeneScreen 1:157-164(2001).
Petry F.,et al.Biochem. Biophys. Res. Commun. 300:343-350(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nagase T.,et al.DNA Res. 8:179-187(2001).
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