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ABCA5 Antibody

Rabbit Polyclonal Antibody

     
  • WB - ABCA5 Antibody ALS14675
    0
    detail
  • IHC - ABCA5 Antibody ALS14675
    Anti-ABCA5 antibody IHC of human prostate.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8WWZ7
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 187kDa
Dilution IHC-P (1:100)
Additional Information
Gene ID 23461
Other Names ATP-binding cassette sub-family A member 5, ABCA5, KIAA1888
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsABCA5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCA5 (HGNC:35)
Synonyms KIAA1888
Function Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity).
Cellular Location Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8CF82}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CF82}. Lysosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Late endosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Cell membrane {ECO:0000250|UniProtKB:Q8K448}. Note=Localized at cell membrane under high cholesterol levels. {ECO:0000250|UniProtKB:Q8K448}
Tissue Location Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath (PubMed:24831815). Expressed in multiple regions of the brain, including the hippocampus, superior frontal and inferior temporal cortices (PubMed:25125465). Strongly expressed in neurons and moderately in microglia, with only weak expression in astrocytes and oligodendrocytes (PubMed:25125465). {ECO:0000269|PubMed:12504089, ECO:0000269|PubMed:24831815, ECO:0000269|PubMed:25125465, ECO:0000269|Ref.1}
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

May play a role in the processing of autolysosomes.

References

Arnould I.,et al.GeneScreen 1:157-164(2001).
Petry F.,et al.Biochem. Biophys. Res. Commun. 300:343-350(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nagase T.,et al.DNA Res. 8:179-187(2001).

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Discontinued
Cat# ALS14675
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