|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:40000), IHC-P (1:100), WB (1:500-1:1000)|
|Other Names||E3 ubiquitin-protein ligase RNF144A, 6.3.2.-, RING finger protein 144A, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4, RNF144A, KIAA0161, RNF144, UBCE7IP4|
|Target/Specificity||RNF144A Antibody detects endogenous levels of total RNF144A protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||RNF144A / RNF144 Antibody (aa151-200) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0161, RNF144, UBCE7IP4|
|Function||E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.|
|Cellular Location||Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane|
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Provided below are standard protocols that you may find useful for product applications.
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.
Nagase T.,et al.DNA Res. 3:17-24(1996).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Martinez-Noel G.,et al.FEBS Lett. 454:257-261(1999).
Ho S.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 111:E2646-E2655(2014).
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