|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.01-0.03 µg/ml)|
|Other Names||Poly(rC)-binding protein 1, Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1, Nucleic acid-binding protein SUB2.3, PCBP1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||HnRNP-E1 / PCBP1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943).|
|Cellular Location||Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm|
|Tissue Location||Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands|
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Provided below are standard protocols that you may find useful for product applications.
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
Leffers H.,et al.Eur. J. Biochem. 230:447-453(1995).
Kiledjian M.,et al.EMBO J. 14:4357-4364(1995).
Aasheim H.-C.,et al.Nucleic Acids Res. 22:959-964(1994).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
Olsen J.V.,et al.Cell 127:635-648(2006).
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