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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MLKL Antibody (clone 3B2)   

MLKL Antibody (clone 3B2)

Mouse Monoclonal Antibody

     
  • IHC - MLKL Antibody (clone 3B2) ALS14684
    Anti-MLKL antibody IHC of human brain, cortex neurons.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8NB16
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3B2
Calculated MW 54kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 197259
Other Names Mixed lineage kinase domain-like protein, hMLKL, MLKL {ECO:0000312|EMBL:AAH28141.1}
Target/Specificity Human MLKL
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsMLKL Antibody (clone 3B2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MLKL {ECO:0000312|EMBL:AAH28141.1}
Function Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Cellular Location Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction
Research Areas
Citations (0)

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Background

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

References

Manning G.,et al.Science 298:1912-1934(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 450.00
Cat# ALS14684
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