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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL17RA Antibody (Internal)   

IL17RA Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - IL17RA Antibody (Internal) ALS14687
    Staining of Rat Kidney lysate (35 ug protein in RIPA buffer) with IL17RA antibody (1 ug/ml).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96F46
Reactivity Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Calculated MW 96kDa
Dilution ELISA (1:8000), IHC-P (5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 23765
Other Names Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CDw217, CD217, IL17RA, IL17R
Target/Specificity Mouse IL17RA / IL-17RA.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsIL17RA Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL17RA
Synonyms IL17R
Function Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.

References

Yao Z.,et al.Cytokine 9:794-800(1997).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
Li W.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS14687
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