|Application ||IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:1000), IF (1:100-1:500), IHC-P (10 µg/ml)|
|Other Names||Copper-transporting ATPase 2, 184.108.40.206, Copper pump 2, Wilson disease-associated protein, WND/140 kDa, ATP7B, PWD, WC1, WND|
|Target/Specificity||ATP7B Antibody detects endogenous levels of total ATP7B protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||WC1 / ATP7B Antibody (aa161-210) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PWD, WC1, WND|
|Function||Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels Isoform 2: Cytoplasm|
|Tissue Location||Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver The cleaved form WND/140 kDa is found in liver cell lines and other tissues|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Petrukhin K.,et al.Hum. Mol. Genet. 3:1647-1656(1994).
Carlini E.J.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).
Oh W.J.,et al.Biochem. Biophys. Res. Commun. 259:206-211(1999).
Bull P.C.,et al.Nat. Genet. 5:327-337(1993).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.