|Application ||WB, IHC-P|
|Reactivity||Human, Rabbit, Monkey, Bovine, Dog|
|Dilution||IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||Serine protease hepsin, 188.8.131.52, Transmembrane protease serine 1, Serine protease hepsin non-catalytic chain, Serine protease hepsin catalytic chain, HPN, TMPRSS1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||HPN / TMPRSS1 / Hepsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Present in most tissues, with the highest level in liver|
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Provided below are standard protocols that you may find useful for product applications.
Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.
Leytus S.P.,et al.Biochemistry 27:1067-1074(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Tsuji A.,et al.J. Biol. Chem. 266:16948-16953(1991).
Torres-Rosado A.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:7181-7185(1993).
Chen R.,et al.J. Proteome Res. 8:651-661(2009).
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