|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml), WB (1:200),|
|Other Names||G-protein coupled receptor 35, Kynurenic acid receptor, KYNA receptor, GPR35|
|Target/Specificity||Successfully detects this receptor in human and mouse intestine samples as well as in human, mouse, and porcine lymphocytes at 30 kDa on immunoblot.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||GPR35 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Internalized to the cytoplasm after exposure to kynurenic acid|
|Tissue Location||Predominantly expressed in immune and gastrointestinal tissues.|
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Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
O'Dowd B.F.,et al.Genomics 47:310-313(1998).
Horikawa Y.,et al.Nat. Genet. 26:163-175(2000).
Warren C.N.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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