|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Sheep, Bovine|
|Dilution||IHC-P (5 µg/ml), WB (1:200),|
|Other Names||Prostaglandin E synthase 2, Membrane-associated prostaglandin E synthase-2, mPGE synthase-2, Microsomal prostaglandin E synthase 2, mPGES-2, Prostaglandin-H(2) E-isomerase, 220.127.116.11, Prostaglandin E synthase 2 truncated form, PTGES2, C9orf15, PGES2|
|Target/Specificity||Does not cross react with mPGES-1 or cPGES.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||PTGES2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).|
|Cellular Location||Golgi apparatus membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer|
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Provided below are standard protocols that you may find useful for product applications.
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
Tanikawa N.,et al.Biochem. Biophys. Res. Commun. 291:884-889(2002).
Watanabe K.,et al.Biochem. Biophys. Res. Commun. 306:577-581(2003).
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