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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ANAPC11 / APC11 Antibody (Internal)   

ANAPC11 / APC11 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - ANAPC11 / APC11 Antibody (Internal) ALS14708
    Immunofluorescence of APC11 in 3T3 cells with APC11 antibody at 20 ug/ml.
  • WB - ANAPC11 / APC11 Antibody (Internal) ALS14708
    Western blot of APC11 in 3T3 cell tissue lysate with APC11 antibody at (A) 1 and (B) 2 ug/ml.
  • IHC - ANAPC11 / APC11 Antibody (Internal) ALS14708
    Anti-ANAPC11 / APC11 antibody IHC of human uterus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9NYG5
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 10kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 51529
Other Names Anaphase-promoting complex subunit 11, APC11, Cyclosome subunit 11, Hepatocellular carcinoma-associated RING finger protein, ANAPC11
Target/Specificity Human ANAPC11
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsANAPC11 / APC11 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANAPC11
Function Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte
Research Areas
Citations (0)

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Background

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

References

Chan A.H.,et al.J. Cell. Biochem. 83:249-258(2001).
Li N.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Zhang Q.-H.,et al.Genome Res. 10:1546-1560(2000).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Gmachl M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:8973-8978(2000).

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$ 395.00
Cat# ALS14708
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