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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PRKAB1 / AMPK Beta 1 Antibody (aa147-196)   

PRKAB1 / AMPK Beta 1 Antibody (aa147-196)

Rabbit Polyclonal Antibody

     
  • WB - PRKAB1 / AMPK Beta 1 Antibody (aa147-196) ALS14719
    Western blot of extracts from HepG2/Jurkat/HUVEC/MCF-7 cells, using PRKAB1 antibody.
  • IHC - PRKAB1 / AMPK Beta 1 Antibody (aa147-196) ALS14719
    Anti-PRKAB1 antibody IHC of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y478
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 30kDa
Dilution ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 5564
Other Names 5'-AMP-activated protein kinase subunit beta-1, AMPK subunit beta-1, AMPKb, PRKAB1, AMPK
Target/Specificity PRKAB1 antibody detects endogenous levels of total AMPK beta1 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsPRKAB1 / AMPK Beta 1 Antibody (aa147-196) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRKAB1
Synonyms AMPK
Function Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Volume 50 µl
Research Areas
Citations (0)

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Background

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

References

Carling D.,et al.Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
Stapleton D.,et al.FEBS Lett. 409:452-456(1997).
Yamagata K.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Wang X.,et al.Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).

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$ 395.00
Cat# ALS14719
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