|Application ||WB, IHC-P, IF, E|
|Dilution||ELISA (1:20000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) ,|
|Other Names||Calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, DREAM, Kv channel-interacting protein 3, KChIP3, KCNIP3, CSEN, DREAM, KCHIP3|
|Target/Specificity||Calsenilin/KCNIP3 antibody detects endogenous levels of total Calsenilin/KCNIP3 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||KCNIP3 / Dream / Calsenilin Antibody (aa29-78) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CSEN, DREAM, KCHIP3|
|Function||Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Lipid-anchor Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus|
|Tissue Location||Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
Buxbaum J.D.,et al.Nat. Med. 4:1177-1181(1998).
Carrion A.M.,et al.Nature 398:80-84(1999).
An W.F.,et al.Nature 403:553-556(2000).
Pruunsild P.,et al.Genomics 86:581-593(2005).
Isbrandt D.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
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