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SSB / La Antibody (aa341-390)

Rabbit Polyclonal Antibody

     
  • WB - SSB / La Antibody (aa341-390) ALS14733
    Western blot of extracts from COLO cells, using SSB antibody.
  • IHC - SSB / La Antibody (aa341-390) ALS14733
    Anti-SSB antibody IHC of human breast.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P05455
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 47kDa
Dilution ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 6741
Other Names Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB
Target/Specificity SSB antibody detects endogenous levels of total SSB protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSSB / La Antibody (aa341-390) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SSB
Function Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
Cellular Location Nucleus.
Volume 50 µl
Research Areas
Citations (0)

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Background

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

References

Chan E.K.L.,et al.Nucleic Acids Res. 17:2233-2244(1989).
Chambers J.C.,et al.J. Biol. Chem. 263:18043-18051(1988).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 395.00
Cat# ALS14733
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