|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Zinc transporter ZIP14, LIV-1 subfamily of ZIP zinc transporter 4, LZT-Hs4, Solute carrier family 39 member 14, Zrt- and Irt-like protein 14, ZIP-14, SLC39A14, KIAA0062, ZIP14|
|Target/Specificity||Human SLC39A14. At least three isoforms of ZIP14 are known to exist; this antibody will detect both isoforms. ZIP14 antibody is predicted to not cross-react with other ZIP family members.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||SLC39A14 / ZIP14 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell projection, lamellipodium Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae|
|Tissue Location||Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.
Nomura N.,et al.DNA Res. 1:223-229(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Taylor K.M.,et al.Biochim. Biophys. Acta 1611:16-30(2003).
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