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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KL / Klotho Antibody (Internal)   

KL / Klotho Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - KL / Klotho Antibody (Internal) ALS14737
    Immunofluorescence of KLOTHO in mouse heart tissue with KLOTHO antibody at 20 ug/ml.
  • WB - KL / Klotho Antibody (Internal) ALS14737
    Western blot analysis of KLOTHO in rat heart tissue lysate with KLOTHO antibody at (A) 1 and (B)...
  • IHC - KL / Klotho Antibody (Internal) ALS14737
    Anti-Klotho antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q9UEF7
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 116kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 9365
Other Names Klotho, 3.2.1.31, Klotho peptide, KL
Target/Specificity Human KL / Klotho. Three isoforms of KLOTHO are known to exist.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsKL / Klotho Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KL
Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O35082}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O35082}. Note=Isoform 1 shedding leads to a soluble peptide {ECO:0000250|UniProtKB:O35082} Klotho peptide: Secreted {ECO:0000250|UniProtKB:O35082}
Tissue Location Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney
Volume 50 µl
Research Areas
Citations (0)

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Background

May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).

References

Kuro-o M.,et al.Nature 390:45-51(1997).
Matsumura Y.,et al.Biochem. Biophys. Res. Commun. 242:626-630(1998).
Dunham A.,et al.Nature 428:522-528(2004).
Kato Y.,et al.Biochem. Biophys. Res. Commun. 267:597-602(2000).
Yahata K.,et al.J. Mol. Med. 78:389-394(2000).

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$ 395.00
Cat# ALS14737
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