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GRIN1 / NMDAR1 Antibody (aa864-913)

Rabbit Polyclonal Antibody

     
  • WB - GRIN1 / NMDAR1 Antibody (aa864-913) ALS14740
    Western blot of extracts from Jurkat cells, using NMDAR1 antibody.
  • IHC - GRIN1 / NMDAR1 Antibody (aa864-913) ALS14740
    Anti-GRIN1 / NMDAR1 antibody IHC of human brain, cortex neurons.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q05586
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 105kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 2902
Other Names Glutamate receptor ionotropic, NMDA 1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, GRIN1, NMDAR1
Target/Specificity NMDAR1 antibody detects endogenous levels of total NMDAR1 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsGRIN1 / NMDAR1 Antibody (aa864-913) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIN1
Synonyms NMDAR1
Function NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Note=Enriched in postsynaptic plasma membrane and postsynaptic densities.
Research Areas
Citations (0)

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Background

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).

References

Foldes R.L.,et al.Gene 131:293-298(1993).
Karp S.J.,et al.J. Biol. Chem. 268:3728-3733(1993).
Planells-Cases R.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:5057-5061(1993).
Zimmer M.,et al.Gene 159:219-223(1995).
Nash N.R.,et al.J. Neurochem. 69:485-493(1997).

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$ 395.00
Cat# ALS14740
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