|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein, LRRTM2, KIAA0416, LRRN2|
|Target/Specificity||Human LRRTM2. LRRTM2 antibody is predicted to not cross-react with other LRRTM family members.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||LRRTM2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein Note=Localized to excitatory synapses.|
|Tissue Location||Expressed in neuronal tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).
Lauren J.,et al.Genomics 81:411-421(2003).
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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