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>   home   >   Products   >   Primary Antibodies   >   TRIP / LRRFIP1 Antibody (C-Terminus)   

TRIP / LRRFIP1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - TRIP / LRRFIP1 Antibody (C-Terminus) ALS14768
    Immunofluorescence of LRRFIP1 in human colon tissue with LRRFIP1 antibody at 20 ug/ml.
  • WB - TRIP / LRRFIP1 Antibody (C-Terminus) ALS14768
    Western blot analysis of LRRFIP1 in human colon tissue lysate with LRRFIP1 antibody at 1 ug/ml.
  • IHC - TRIP / LRRFIP1 Antibody (C-Terminus) ALS14768
    Anti-LRRFIP1 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q32MZ4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 89kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 9208
Other Names Leucine-rich repeat flightless-interacting protein 1, LRR FLII-interacting protein 1, GC-binding factor 2, TAR RNA-interacting protein, LRRFIP1, GCF2, TRIP
Target/Specificity Human LRRFIP1. LRRFIP1 antibody is predicted to not cross-react with other LRRFIP family members. Three isoforms of LRRFIP1 are known to exist; this antibody will only recognize the two longer isoforms.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsTRIP / LRRFIP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRRFIP1
Synonyms GCF2, TRIP
Function Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Cellular Location Nucleus. Cytoplasm.
Tissue Location Ubiquitously expressed.
Citations (0)

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Background

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

References

Reed A.L.,et al.J. Biol. Chem. 273:21594-21602(1998).
Wilson S.A.,et al.Nucleic Acids Res. 26:3460-3467(1998).
Hillier L.W.,et al.Nature 434:724-731(2005).
Fong K.S.K.,et al.Genomics 58:146-157(1999).
Khachigian L.M.,et al.Circ. Res. 84:1258-1267(1999).

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$ 395.00
Cat# ALS14768
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