|Application ||WB, IHC-P, IF|
|Calculated MW||54206 Da|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Myocardial zonula adherens protein, GRINL1A upstream protein, Gup, MYZAP, MYOZAP|
|Target/Specificity||Human GCOM1. Multiple isoforms of MYOZAP are known to exist.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||MYZAP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, Z line. Cell junction. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin (By similarity).|
|Tissue Location||Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis|
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