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C-TAK1 / MARK3 Antibody (aa1-50)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P27448 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 84kDa |
| Dilution | ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
| Gene ID | 4140 |
|---|---|
| Other Names | MAP/microtubule affinity-regulating kinase 3, 2.7.11.1, C-TAK1, cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Par-1a, Serine/threonine-protein kinase p78, MARK3, CTAK1, EMK2 |
| Target/Specificity | MARK3 Antibody detects endogenous levels of total MARK3 protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | C-TAK1 / MARK3 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MARK3 |
|---|---|
| Synonyms | CTAK1, EMK2 |
| Function | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). |
| Cellular Location | Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm |
| Tissue Location | Ubiquitous. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
References
Peng C.Y.,et al.Cell Growth Differ. 9:197-208(1998).
Waggoner S.N.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Sun T.-Q.,et al.Nat. Cell Biol. 3:628-636(2001).
Drewes G.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Maheshwari K.K.,et al.Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases.
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