|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||MAP/microtubule affinity-regulating kinase 3, 220.127.116.11, C-TAK1, cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Par-1a, Serine/threonine-protein kinase p78, MARK3, CTAK1, EMK2|
|Target/Specificity||MARK3 Antibody detects endogenous levels of total MARK3 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||C-TAK1 / MARK3 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.|
|Cellular Location||Cell membrane; Peripheral membrane protein|
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Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
Peng C.Y.,et al.Cell Growth Differ. 9:197-208(1998).
Waggoner S.N.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Sun T.-Q.,et al.Nat. Cell Biol. 3:628-636(2001).
Drewes G.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Maheshwari K.K.,et al.Submitted (JAN-1992) to the EMBL/GenBank/DDBJ databases.
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