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EP / DBI Antibody (clone 27C9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP |
|---|---|
| Primary Accession | P07108 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 27C9 |
| Calculated MW | 10kDa |
| Dilution | IHC-P (1:200), WB (1:100-1:500), |
| Gene ID | 1622 |
|---|---|
| Other Names | Acyl-CoA-binding protein, ACBP, Diazepam-binding inhibitor, DBI, Endozepine, EP, DBI |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | EP / DBI Antibody (clone 27C9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DBI |
|---|---|
| Function | Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. |
| Cellular Location | Endoplasmic reticulum. Golgi apparatus Note=Golgi localization is dependent on ligand binding (PubMed:17953517). |
| Tissue Location | Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
References
Gray P.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:7547-7551(1986).
Webb N.R.,et al.DNA 6:71-79(1987).
Nitz I.,et al.Int. J. Biochem. Cell Biol. 37:2395-2405(2005).
Ludewig A.H.,et al.IUBMB Life 63:547-552(2011).
Nitz I.,et al.J. Cell. Mol. Med. 15:909-927(2011).
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